A rotating operant chamber for use with microdialysis

A novel contextual dimension for use with an operant chamber: from simple to hierarchical forms of learning.

A novel procedure is described in which the floor temperatures (warm and cool) in an operant chamber are used as contextual cues in 2 experiments with rats. Experiment 1 demonstrated that rats learn the relationship between these thermal contexts and auditory stimuli that have been paired with them. Experiment 2 showed that thermal contexts can serve a conditional function that (a) reflects the...

Rotating Combustion Chamber for Rocket Apparatus

the use of operant methods to evaluate interventions for patients with myalgic encephalomyelitis

introduction the current study provides data from two patients with myalgic encephalomyelitis, who charted several of their symptoms over time. case presentation each patient charted domains that were relevant to them, and they were attempting to assess the effects of specific interventions. an ab operant design was used for both participants. the findings indicate that by charting symptoms on ...

Microdialysis of ethanol during operant ethanol self-administration and ethanol determination by gas chromatography.

Operant self-administration methods are commonly used to study the behavioral and pharmacological effects of many drugs of abuse, including ethanol. However, ethanol is typically self-administered orally, rather than intravenously like many other drugs of abuse. The pharmacokinetics of orally administered drugs are more complex than intravenously administered drugs. Because understanding the re...

Suspended, Porous Cellulose Acetate Membranes For Microdialysis Use

Porous cellulose acetate membranes were suspended over 75 micron wide silicon microchannels. The microchannels are formed when a viscous polymer lacquer is directly spin cast onto etched silicon cavities (Fig. 1). Standard fabrication processes are used to create the channel, preventing the need for adhesives, substrate bonding, or other complex assembly procedures. These microchannels can allo...